PhytophthoraV1, Main, Exploration, bibRecord, 000596

A Phytophthora capsici Effector Targets ACD11 Binding Partners that Regulate ROS-Mediated Defense Response in Arabidopsis.

Identifieur interne : 000596 ( Main/Exploration ); précédent : 000595; suivant : 000597

A Phytophthora capsici Effector Targets ACD11 Binding Partners that Regulate ROS-Mediated Defense Response in Arabidopsis.

Source :

Molecular plant [ 1752-9867 ] ; 2019.

RBID : pubmed:30703564

Descripteurs français

KwdFr :
- Arabidopsis (génétique), Arabidopsis (immunologie), Arabidopsis (microbiologie), Arabidopsis (métabolisme), Espèces réactives de l'oxygène (métabolisme), Facteurs de virulence (métabolisme), Immunité des plantes (MeSH), Liaison aux protéines (MeSH), Mutation (MeSH), Phytophthora (métabolisme), Phytophthora (physiologie), Protéines d'Arabidopsis (génétique), Protéines d'Arabidopsis (métabolisme), Protéines de transport membranaire (génétique), Protéines de transport membranaire (métabolisme), Protéines régulatrices de l'apoptose (génétique), Protéines régulatrices de l'apoptose (métabolisme).
MESH :
- génétique : Arabidopsis, Protéines d'Arabidopsis, Protéines de transport membranaire, Protéines régulatrices de l'apoptose.
- immunologie : Arabidopsis.
- microbiologie : Arabidopsis.
- métabolisme : Arabidopsis, Espèces réactives de l'oxygène, Facteurs de virulence, Phytophthora, Protéines d'Arabidopsis, Protéines de transport membranaire, Protéines régulatrices de l'apoptose.
- physiologie : Phytophthora.
- Immunité des plantes, Liaison aux protéines, Mutation.

English descriptors

KwdEn :
- Apoptosis Regulatory Proteins (genetics), Apoptosis Regulatory Proteins (metabolism), Arabidopsis (genetics), Arabidopsis (immunology), Arabidopsis (metabolism), Arabidopsis (microbiology), Arabidopsis Proteins (genetics), Arabidopsis Proteins (metabolism), Membrane Transport Proteins (genetics), Membrane Transport Proteins (metabolism), Mutation (MeSH), Phytophthora (metabolism), Phytophthora (physiology), Plant Immunity (MeSH), Protein Binding (MeSH), Reactive Oxygen Species (metabolism), Virulence Factors (metabolism).
MESH :
- chemical , genetics : Apoptosis Regulatory Proteins, Arabidopsis Proteins, Membrane Transport Proteins.
- chemical , metabolism : Apoptosis Regulatory Proteins, Arabidopsis Proteins, Membrane Transport Proteins, Reactive Oxygen Species, Virulence Factors.
- genetics : Arabidopsis.
- immunology : Arabidopsis.
- metabolism : Arabidopsis, Phytophthora.
- microbiology : Arabidopsis.
- physiology : Phytophthora.
- Mutation, Plant Immunity, Protein Binding.

Abstract

Reactive oxygen species (ROS) play a vital role in plant immune response, but the genes involved in the regulation of ROS are scantily reported. Phytophthora pathogens produce a large number of effectors to promote infection, but the modes of action adopted are largely unknown. Here, we report that RxLR207 could activate ROS-mediated cell death in Nicotiana benthamiana and was essential for virulence of P. capsici. We found that this effector targeted BPA1 (binding partner of ACD11) and four members of BPLs (BPA1-Like proteins) in Arabidopsis, and the bpa1 and bpl mutants had enhanced ROS accumulation and cell death under biotic or abiotic stresses. Furthermore, we showed that BPA1 and several BPLs functioned redundantly in plant immunity to P. capsici. We discovered that BPA1 and all six BPLs interacted with ACD11, and stabilization of ACD11 was impaired in the bpa1, bpl2, bpl3, and bpl4 mutants. RxLR207 could promote the degradation of BPA1, BPL1, BPL2, and BPL4 to disrupt ACD11 stabilization in a 26S proteasome-dependent manner. Taken together, these findings indicate the important roles of Arabidopsis BPA1 and its homologs in ROS homeostasis and defense response, highlighting the usefulness of a pathogen effector-directed approach as a promising strategy for the discovery of novel plant immune regulators.

DOI: 10.1016/j.molp.2019.01.018
PubMed: 30703564

Affiliations:

République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000557
to stream Main, to step Curation: 000557

Le document en format XML

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<series><title level="j">Molecular plant</title>
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<term>Arabidopsis (immunology)</term>
<term>Arabidopsis (metabolism)</term>
<term>Arabidopsis (microbiology)</term>
<term>Arabidopsis Proteins (genetics)</term>
<term>Arabidopsis Proteins (metabolism)</term>
<term>Membrane Transport Proteins (genetics)</term>
<term>Membrane Transport Proteins (metabolism)</term>
<term>Mutation (MeSH)</term>
<term>Phytophthora (metabolism)</term>
<term>Phytophthora (physiology)</term>
<term>Plant Immunity (MeSH)</term>
<term>Protein Binding (MeSH)</term>
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<term>Arabidopsis (immunologie)</term>
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<term>Espèces réactives de l'oxygène (métabolisme)</term>
<term>Facteurs de virulence (métabolisme)</term>
<term>Immunité des plantes (MeSH)</term>
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<term>Mutation (MeSH)</term>
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<term>Phytophthora (physiologie)</term>
<term>Protéines d'Arabidopsis (génétique)</term>
<term>Protéines d'Arabidopsis (métabolisme)</term>
<term>Protéines de transport membranaire (génétique)</term>
<term>Protéines de transport membranaire (métabolisme)</term>
<term>Protéines régulatrices de l'apoptose (génétique)</term>
<term>Protéines régulatrices de l'apoptose (métabolisme)</term>
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<term>Arabidopsis Proteins</term>
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<term>Protéines d'Arabidopsis</term>
<term>Protéines de transport membranaire</term>
<term>Protéines régulatrices de l'apoptose</term>
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<term>Espèces réactives de l'oxygène</term>
<term>Facteurs de virulence</term>
<term>Phytophthora</term>
<term>Protéines d'Arabidopsis</term>
<term>Protéines de transport membranaire</term>
<term>Protéines régulatrices de l'apoptose</term>
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<term>Protein Binding</term>
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<front><div type="abstract" xml:lang="en">Reactive oxygen species (ROS) play a vital role in plant immune response, but the genes involved in the regulation of ROS are scantily reported. Phytophthora pathogens produce a large number of effectors to promote infection, but the modes of action adopted are largely unknown. Here, we report that RxLR207 could activate ROS-mediated cell death in Nicotiana benthamiana and was essential for virulence of P. capsici. We found that this effector targeted BPA1 (binding partner of ACD11) and four members of BPLs (BPA1-Like proteins) in Arabidopsis, and the bpa1 and bpl mutants had enhanced ROS accumulation and cell death under biotic or abiotic stresses. Furthermore, we showed that BPA1 and several BPLs functioned redundantly in plant immunity to P. capsici. We discovered that BPA1 and all six BPLs interacted with ACD11, and stabilization of ACD11 was impaired in the bpa1, bpl2, bpl3, and bpl4 mutants. RxLR207 could promote the degradation of BPA1, BPL1, BPL2, and BPL4 to disrupt ACD11 stabilization in a 26S proteasome-dependent manner. Taken together, these findings indicate the important roles of Arabidopsis BPA1 and its homologs in ROS homeostasis and defense response, highlighting the usefulness of a pathogen effector-directed approach as a promising strategy for the discovery of novel plant immune regulators.</div>
</front>
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<Abstract><AbstractText>Reactive oxygen species (ROS) play a vital role in plant immune response, but the genes involved in the regulation of ROS are scantily reported. Phytophthora pathogens produce a large number of effectors to promote infection, but the modes of action adopted are largely unknown. Here, we report that RxLR207 could activate ROS-mediated cell death in Nicotiana benthamiana and was essential for virulence of P. capsici. We found that this effector targeted BPA1 (binding partner of ACD11) and four members of BPLs (BPA1-Like proteins) in Arabidopsis, and the bpa1 and bpl mutants had enhanced ROS accumulation and cell death under biotic or abiotic stresses. Furthermore, we showed that BPA1 and several BPLs functioned redundantly in plant immunity to P. capsici. We discovered that BPA1 and all six BPLs interacted with ACD11, and stabilization of ACD11 was impaired in the bpa1, bpl2, bpl3, and bpl4 mutants. RxLR207 could promote the degradation of BPA1, BPL1, BPL2, and BPL4 to disrupt ACD11 stabilization in a 26S proteasome-dependent manner. Taken together, these findings indicate the important roles of Arabidopsis BPA1 and its homologs in ROS homeostasis and defense response, highlighting the usefulness of a pathogen effector-directed approach as a promising strategy for the discovery of novel plant immune regulators.</AbstractText>
<CopyrightInformation>Copyright © 2019 The Author. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
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<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shen</LastName>
<ForeName>Danyu</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zou</LastName>
<ForeName>Fen</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bai</LastName>
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<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
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<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Meixiang</ForeName>
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<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jing</LastName>
<ForeName>Maofeng</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dou</LastName>
<ForeName>Daolong</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China. Electronic address: ddou@njau.edu.cn.</Affiliation>
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<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>01</Month>
<Day>28</Day>
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<NlmUniqueID>101465514</NlmUniqueID>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C451029">ACD11 protein, Arabidopsis</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D051017">Apoptosis Regulatory Proteins</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D029681">Arabidopsis Proteins</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
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<Chemical><RegistryNumber>0</RegistryNumber>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D051017" MajorTopicYN="N">Apoptosis Regulatory Proteins</DescriptorName>
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<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
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<QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
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<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057865" MajorTopicYN="N">Plant Immunity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D037521" MajorTopicYN="N">Virulence Factors</DescriptorName>
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</MeshHeading>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">ACD11</Keyword>
<Keyword MajorTopicYN="Y">Arabidopsis</Keyword>
<Keyword MajorTopicYN="Y">BPA1</Keyword>
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<Keyword MajorTopicYN="Y">ROS</Keyword>
<Keyword MajorTopicYN="Y">RxLR effector</Keyword>
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</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>07</Month>
<Day>28</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2019</Year>
<Month>01</Month>
<Day>20</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2019</Year>
<Month>01</Month>
<Day>20</Day>
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<Hour>6</Hour>
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<ArticleId IdType="doi">10.1016/j.molp.2019.01.018</ArticleId>
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<affiliations><list><country><li>République populaire de Chine</li>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Li, Qi" sort="Li, Qi" uniqKey="Li Q" first="Qi" last="Li">Qi Li</name>
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<name sortKey="Ai, Gan" sort="Ai, Gan" uniqKey="Ai G" first="Gan" last="Ai">Gan Ai</name>
<name sortKey="Bai, Tian" sort="Bai, Tian" uniqKey="Bai T" first="Tian" last="Bai">Tian Bai</name>
<name sortKey="Chen, Yanyu" sort="Chen, Yanyu" uniqKey="Chen Y" first="Yanyu" last="Chen">Yanyu Chen</name>
<name sortKey="Dou, Daolong" sort="Dou, Daolong" uniqKey="Dou D" first="Daolong" last="Dou">Daolong Dou</name>
<name sortKey="Jing, Maofeng" sort="Jing, Maofeng" uniqKey="Jing M" first="Maofeng" last="Jing">Maofeng Jing</name>
<name sortKey="Li, Shutian" sort="Li, Shutian" uniqKey="Li S" first="Shutian" last="Li">Shutian Li</name>
<name sortKey="Shen, Danyu" sort="Shen, Danyu" uniqKey="Shen D" first="Danyu" last="Shen">Danyu Shen</name>
<name sortKey="Wang, Ji" sort="Wang, Ji" uniqKey="Wang J" first="Ji" last="Wang">Ji Wang</name>
<name sortKey="Zhang, Meixiang" sort="Zhang, Meixiang" uniqKey="Zhang M" first="Meixiang" last="Zhang">Meixiang Zhang</name>
<name sortKey="Zou, Fen" sort="Zou, Fen" uniqKey="Zou F" first="Fen" last="Zou">Fen Zou</name>
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A Phytophthora capsici Effector Targets ACD11 Binding Partners that Regulate ROS-Mediated Defense Response in Arabidopsis.

A Phytophthora capsici Effector Targets ACD11 Binding Partners that Regulate ROS-Mediated Defense Response in Arabidopsis.

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